C0000511 - A quinoline derivative with potent tumorigenic activity. 4-nitroquinoline-1-oxide (4-NQO) potentially induces DNA damage by either binding directly to DNA and disrupting replication or through the generation of reactive oxygen species (ROS). 4-NQO is also metabolized to form other mutagenic compounds, such as 8-hydroxy-2'-deoxyguanosine.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0000511

Russian	Medical Subject Headings Russian	D015112	L3334942	preferred	S3862421	Y	4-НИТРОХИНОЛИН-1-ОКСИД
Russian	Medical Subject Headings Russian	D015112	L0889327	no	S1093144	Y	4-NITROKHINOLIN-1-OKSID
Russian	Medical Subject Headings Russian	D015112	L1507236	no	S1803145	Y	4-NITROKHINOLIN-N-OKSID
Russian	Medical Subject Headings Russian	D015112	L3334943	no	S3862422	Y	4-НИТРОХИНОЛИН-N-ОКСИД
	Medical Subject Headings				A0017292	AT38136103	A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage.
	NCI NCI Dictionary of Cancer Terms				A7640224	AT198028567	A substance that is used in cancer research to cause tumors in laboratory animals. This is done to test new diets, drugs, and procedures for use in cancer prevention and treatment.
	NCI Thesaurus				A7640224	AT220002160	A quinoline derivative with potent tumorigenic activity. 4-nitroquinoline-1-oxide (4-NQO) potentially induces DNA damage by either binding directly to DNA and disrupting replication or through the generation of reactive oxygen species (ROS). 4-NQO is also metabolized to form other mutagenic compounds, such as 8-hydroxy-2'-deoxyguanosine.