C0000610 - A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway coenzyme) analog that inhibits NAD-dependent enzyme activity associated with ATP production. 6-Aminonicotinamide impairs cartilage formation, may have teratogenic effects, and enhances the effect of radiation and cisplatin treatment (formation of platinum-DNA complexes). (NCI04)

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0000610

Russian	Medical Subject Headings Russian	D015120	L3334993	preferred	S3862474	Y	6-АМИНОНИКОТИНАМИД
Russian	Medical Subject Headings Russian	D015120	L0889338	no	S1093155	Y	6-AMINONIKOTINAMID
	Medical Subject Headings				A0017483	AT38152432	A vitamin antagonist which has teratogenic effects.
	NCI Thesaurus				A7568459	AT198103748	A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway coenzyme) analog that inhibits NAD-dependent enzyme activity associated with ATP production. 6-Aminonicotinamide impairs cartilage formation, may have teratogenic effects, and enhances the effect of radiation and cisplatin treatment (formation of platinum-DNA complexes). (NCI04)