C0000618 - A drug used to treat acute lymphatic leukemia. It belongs to the family of drugs called antimetabolites.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0000618

Russian	Medical Subject Headings Russian	D015122	L14416360	preferred	S17540341	Y	МЕРКАПТОПУРИН
Russian	Medical Subject Headings Russian	D015122	L0889342	no	S1093159	Y	6-MERKAPTOPURIN
Russian	Medical Subject Headings Russian	D015122	L14422695	no	S17524218	Y	PURIMETOL
Russian	Medical Subject Headings Russian	D015122	L14426417	no	S17520826	Y	MERKAPTOPURIN
Russian	Medical Subject Headings Russian	D015122	L14430973	no	S17524217	Y	PURI-NETOL
Russian	Medical Subject Headings Russian	D015122	L14433007	no	S17540685	Y	ПУРИ-НЕТОЛ
Russian	Medical Subject Headings Russian	D015122	L14437041	no	S17540287	Y	ЛЕУПУРИН
Russian	Medical Subject Headings Russian	D015122	L14442741	no	S17520088	Y	LEUPURIN
Russian	Medical Subject Headings Russian	D015122	L14445408	no	S17540686	Y	ПУРИМЕТОЛ
Russian	Medical Subject Headings Russian	D015122	L1509173	no	S1805082	Y	ARABINOZIL-6-MERKAPTOPURIN
Russian	Medical Subject Headings Russian	D015122	L3334999	no	S3862480	Y	6-МЕРКАПТОПУРИН
Russian	Medical Subject Headings Russian	D015122	L3339299	no	S3866777	Y	АРАБИНОЗИЛ-6-МЕРКАПТОПУРИН
	Medical Subject Headings				A28396098	AT38143061	An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
	Medical Subject Headings Czech				A28782994	AT231378874	Merkaptopurin - 6-purinthiol, cytostatikum ze skupiny antimetabolitů, purinový analog (derivátem 6-merkaptopurinu je azathioprin). Používá se v léčbě leukemií. (cit. Velký lékařský slovník online, 2017 http://lekarske.slovniky.cz/ )
	PDQ				A4345940	AT70656663	A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43436&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43436&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C195" NCI Thesaurus)
	NCI Thesaurus				A7572078	AT197991309	A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04)
	NCI NCI Dictionary of Cancer Terms				A7572078	AT198053089	A drug used to treat acute lymphatic leukemia. It belongs to the family of drugs called antimetabolites.