C0000956 - A 4-hydroxycoumarin derivative with anticoagulant activity. As a vitamin K antagonist, acenocoumarol inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity and thus thrombin formation. Compared to other coumarin derivatives, acenocoumarol has a short half-life. 2/10
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Terms, descriptions
CUI    C0000956
RussianMedical Subject Headings Russian D000074 L3369341preferred S3896831 Y СИНКУМАР
RussianMedical Subject Headings Russian D000074 L0904574no S1108391 Y SINKUMAR
RussianMedical Subject Headings Russian D000074 L1509706no S1805615 Y ATSENOKUMARIN
RussianMedical Subject Headings Russian D000074 L1509707no S1805616 Y ATSENOKUMAROL
RussianMedical Subject Headings Russian D000074 L1533242no S1829151 Y NIKUMALON
RussianMedical Subject Headings Russian D000074 L3339951no S3867432 Y АЦЕНОКУМАРИН
RussianMedical Subject Headings Russian D000074 L3339952no S3867433 Y АЦЕНОКУМАРОЛ
RussianMedical Subject Headings Russian D000074 L3360213no S3887700 Y НИКУМАЛОН
Medical Subject Headings A0018213 AT38135412 A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)
NCI Thesaurus A16767929 AT198096057 A 4-hydroxycoumarin derivative with anticoagulant activity. As a vitamin K antagonist, acenocoumarol inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity and thus thrombin formation. Compared to other coumarin derivatives, acenocoumarol has a short half-life.