C0001143 - An oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0001143

Russian	Medical Subject Headings Russian	D015250	L3337377	preferred	S3864858	Y	АКЛАРУБИЦИН
Russian	Medical Subject Headings Russian	D015250	L0889568	no	S1093385	Y	AKLARUBITSIN
Russian	Medical Subject Headings Russian	D015250	L1507929	no	S1803838	Y	AKLATSINOMITSIN A
Russian	Medical Subject Headings Russian	D015250	L3337378	no	S3864859	Y	АКЛАЦИНОМИЦИН A
	Medical Subject Headings				A0019091	AT38148900	An anthracycline produced by Streptomyces galilaeus. It has potent antineoplastic activity.
	PDQ				A4344053	AT70662299	An oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39131&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39131&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C202" NCI Thesaurus)
	NCI Thesaurus				A7568505	AT197966249	An oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin.