C0001186 - A polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0001186

Russian	Medical Subject Headings Russian	D000166	L3337393	preferred	S3864874	Y	АКРИДИНЫ
Russian	Medical Subject Headings Russian	D000166	L0889579	no	S1093396	Y	AKRIDINY
	Medical Subject Headings				A0019204	AT218063871	Compounds that include the structure of acridine.
	(CPTSP) CRISP Thesaurus				A0472747	AT51221593	heterocyclic three ring compound.
	NCI Thesaurus				A7568409	AT198053151	A polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death.