C0002199 - A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40467&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40467&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C225" NCI Thesaurus) 2/10
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Terms, descriptions
CUI    C0002199
RussianMedical Subject Headings Russian D016898 L3350714preferred S3878186 Y ИНТЕРФЕРОН-АЛЬФА
RussianMedical Subject Headings Russian D016898 L0895840no S1099657 Y INTERFERON-AL'FA
RussianMedical Subject Headings Russian D016898 L1508040no S1803949 Y AL'FA-INTERFERON
RussianMedical Subject Headings Russian D016898 L1524706no S1820615 Y INTERFERON AL'FA-2C
RussianMedical Subject Headings Russian D016898 L1524707no S1820616 Y INTERFERON AL'FA
RussianMedical Subject Headings Russian D016898 L1524723no S1820632 Y INTERFERON LEIKOTSITOV
RussianMedical Subject Headings Russian D016898 L1524724no S1820633 Y INTERFERON LIMFOBLASTOV
RussianMedical Subject Headings Russian D016898 L3337817no S3865303 Y АЛЬФА-ИНТЕРФЕРОН
RussianMedical Subject Headings Russian D016898 L3350695no S3878185 Y ИНТЕРФЕРОН АЛЬФА
RussianMedical Subject Headings Russian D016898 L3350699no S3878183 Y ИНТЕРФЕРОН АЛЬФА-2C
RussianMedical Subject Headings Russian D016898 L3350707no S3878199 Y ИНТЕРФЕРОН ЛЕЙКОЦИТОВ
RussianMedical Subject Headings Russian D016898 L3350708no S3878200 Y ИНТЕРФЕРОН ЛИМФОБЛАСТОВ
Medical Subject Headings A0074810 AT73568554 One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
(CPTSP) CRISP Thesaurus A0481917 AT51220718 major interferon produced by virus-exposed leukocytes; has antiviral activity and activates NK cells; used in the treatment of hairy cell leukemia and other neoplasms.
CHV A18552694 AT130673169 a protein produced by the body in response to an infection
CHV A18571088 AT130673170 a protein produced by the body in response to an infection
CHV A18626939 AT130673171 a protein produced by the body in response to an infection
CHV A18626940 AT130673172 a protein produced by the body in response to an infection
CHV A18626941 AT130673173 a protein produced by the body in response to an infection
CHV A18645539 AT130673174 a protein produced by the body in response to an infection
PDQ A4352679 AT70646947 A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40467&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40467&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C225" NCI Thesaurus)