C0002260 - A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39754&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39754&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C226" NCI Thesaurus) 1/10
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Terms, descriptions
CUI    C0002260
RussianMedical Subject Headings Russian D000518 L3378588preferred S3906081 Y ЭФЛОРНИТИН
RussianMedical Subject Headings Russian D000518 L0892655no S1096472 Y EFLORNITIN
RussianMedical Subject Headings Russian D000518 L1508036no S1803945 Y AL'FA-DIFTORMETILORNITIN
RussianMedical Subject Headings Russian D000518 L1515542no S1811451 Y DIFTORMETILORNITIN
RussianMedical Subject Headings Russian D000518 L3337815no S3865298 Y АЛЬФА-ДИФТОРМЕТИЛОРНИТИН
RussianMedical Subject Headings Russian D000518 L3348158no S3875637 Y ДИФТОРМЕТИЛОРНИТИН
Medical Subject Headings A0053038 AT199394641 An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
(CPTSP) CRISP Thesaurus A0828470 AT51224830 polyamine antagonist which reversibly inhibits DNA polymerase and irreversibly inhibits ornithine decarboxylase; used against bladder cancer, with potential applications in epilepsy and PCP withdrawal.
NCI Thesaurus A12806720 AT198003975 A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)
NCI NCI Dictionary of Cancer Terms A12806720 AT198139531 A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals.
CHV A18614179 AT130672573 a drug that is being studied in the treatment of cancer
CHV A18632698 AT130672574 a drug that is being studied in the treatment of cancer
CHV A18651335 AT130672575 a drug that is being studied in the treatment of cancer
PDQ A4345470 AT70659716 A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39754&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39754&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C226" NCI Thesaurus)