C0002395 - A brain disorder that usually starts in late middle age or old age and gets worse over time. Symptoms include loss of memory, confusion, difficulty thinking, and changes in language, behavior, and personality.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0002395

Russian	Medical Subject Headings Russian	D000544	L3337871	preferred	S3865352	Y	АЛЬЦГЕЙМЕРА БОЛЕЗНЬ
Russian	Medical Subject Headings Russian	D000544	L0889687	no	S1093504	Y	AL'TSGEIMERA BOLEZN'
Russian	Medical Subject Headings Russian	D000544	L1515075	no	S1810984	Y	DEMENTSIIA SENIL'NAIA
Russian	MDRRUS	10012271	L15712515	no	S19030072	N	Деменция при болезни Альцгеймера
Russian	MDRRUS	10012271	L15712515	no	S19030072	Y	Деменция при болезни Альцгеймера
Russian	MDRRUS	10001896	L15733522	no	S19020936	Y	Болезнь Альцгеймера
Russian	MDRRUS	10012292	L15767833	no	S19030066	Y	Деменция по типу болезни Альцгеймера, БДУ
Russian	Medical Subject Headings Russian	D000544	L2227054	no	S2565276	Y	DEMENTSIIA PRESENIL'NAIA AL'TSGEIMERA
Russian	Medical Subject Headings Russian	D000544	L2227056	no	S2565278	Y	DEMENTSIIA TIPA AL'TSGEIMERA
Russian	Medical Subject Headings Russian	D000544	L2228290	no	S2566512	Y	SENIL'NAIA DEMENTSIIA SO SPUTANNOST'IU SOZNANIIA
Russian	Medical Subject Headings Russian	D000544	L3347127	no	S3874606	Y	ДЕМЕНЦИЯ ПРЕСЕНИЛЬНАЯ АЛЬЦГЕЙМЕРА
Russian	Medical Subject Headings Russian	D000544	L3347129	no	S3874608	Y	ДЕМЕНЦИЯ СЕНИЛЬНАЯ
Russian	Medical Subject Headings Russian	D000544	L3347132	no	S3874611	Y	ДЕМЕНЦИЯ ТИПА АЛЬЦГЕЙМЕРА
Russian	Medical Subject Headings Russian	D000544	L3368842	no	S3896332	Y	СЕНИЛЬНАЯ ДЕМЕНЦИЯ СО СПУТАННОСТЬЮ СОЗНАНИЯ
	Medical Subject Headings				A0022347	AT43116661	A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
	(CPTSP) CRISP Thesaurus				A0389304	AT51222396	neurodegenerative disorder of the CNS resulting in progressive loss of memory and intellectual functions; begins in the middle or later years; characterized by brain lesions such as neurofibrillary tangles and neuritic plaques.
	Medical Subject Headings Czech				A13040589	AT204246454	Choroba mozku, nejčastější příčina demence. Patří do skupiny atroficko-degenerativních chorob. Některé formy mají familiární výskyt. Presenilní forma začíná do před 65. rokem, senilní forma po této hranici. Postižena je zejm. cholinergní transmise z oblasti bazálních částí mozku do kůry a hipokampu významného pro paměť, postiženy jsou i neurony produkující CRF či somatostatin. Morfologicky jsou změny v neuronech tzv. tangles, popř. Lewyho tělíska a extracelulárně neuritické senilní plaky s prokázanou depozicí amyloidu, kongofilní angiopatie. Je patrno rozšíření komorového systému, atrofie hipokampů. Příčina není známá, jsou popsány mutace některých genů zvyšující riziko vzniku nemoci mj. apolipoprotein E4. V klinickém obrazu je přítomna porucha paměti, kognitivní poruchy typu afázie, apraxie, agnozie, poruchy výkonných funkcí, orientace, citů, motivace. Dochází k výraznému narušení fungování postižené osoby v zaměstnání, sociální sféře, k výraznému postižení osobnosti i v estetické a etické sféře s egocentrismem. Postupně dochází k rozvratu osobnosti, inkontinenci, upoutání na lůžku a úmrtí obv. na interkurentní choroby. Nemoc trvá několik let, rychleji probíhá u familiární a presenilní formy. Diferenciálně diagnosticky je patrný postupný začátek s pomalým, ale plynulým zhoršováním; je nutné vyloučit jinou příčinu tohoto stavu. Léčba je obtížná, nověji se popisují určité pozitivní výsledky zpomalení progrese u časnějších forem. (cit. Velký lékařský slovník online, 2014 http://lekarske.slovniky.cz)
	(JABL) Congenital Mental Retardation Syndromes				A1702699	AT14332587	A disabling degenerative disease of the nervous system occurring in middle-aged or older persons and characterized by dementia and failure of memory for recent events, followed by total incapacitation and death. Types of the Alzheimer syndrome are differentiated by the age of onset and genetic characteristics. The early onset form (the mean age of the onset of symptoms between the ages of 40 and 60 years) and the late onset form (the onset of symptoms after the age of 60 years). Three forms are identified: AD-1, AD-2, AD-3. Some of the clinical characteristics of the Alzheimer syndrome are similar to those of the Pick syndrome.
	MSHNOR				A20191558	AT221521169	En degenerativ hjernesykdom kjennetegnet av gradvis tiltakende demens. Hukommelsessvikt, svekket dømmekraft, konsentrasjonsevne og problemløsningsferdighet etterfølges av alvorlig apraksi og et omfattende tap av kognitive ferdigheter. Tilstanden oppstår først og fremst etter fylte 60 år, og er sterkt preget av alvorlig kortikal atrofi og triaden senile (amyloide) plakk, nevrofibrillnøster og nevropiltråder.
	MEDLINEPLUS				A21144074	AT220102821	Alzheimer's disease (AD) is the most common form of dementia among older people. Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. AD begins slowly. It first involves the parts of the brain that control thought, memory and language. People with AD may have trouble remembering things that happened recently or names of people they know. A related problem, mild cognitive impairment (MCI), causes more memory problems than normal for people of the same age. Many, but not all, people with MCI will develop AD. In AD, over time, symptoms get worse. People may not recognize family members. They may have trouble speaking, reading or writing. They may forget how to brush their teeth or comb their hair. Later on, they may become anxious or aggressive, or wander away from home. Eventually, they need total care. This can cause great stress for family members who must care for them. AD usually begins after age 60. The risk goes up as you get older. Your risk is also higher if a family member has had the disease. No treatment can stop the disease. However, some drugs may help keep symptoms from getting worse for a limited time. NIH: National Institute on Aging
	HPO				A24668637	AT206293897	A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads. [HPO:probinson]
	NCI Thesaurus				A7568669	AT198004540	A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
	NCI NCI Dictionary of Cancer Terms				A7568669	AT198090605	A brain disorder that usually starts in late middle age or old age and gets worse over time. Symptoms include loss of memory, confusion, difficulty thinking, and changes in language, behavior, and personality.