C0002435 - A semisynthetic, broad spectrum beta-lactam penicillin with antibacterial activity. Amdinocillin specifically binds to and inactivates penicillin-binding protein 2 (PBP 2) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Given the fact that most beta-lactam penicillins bind almost exclusively to PBPs 1 and 3, amdinocillin is able to synergize with other penicillins in the treatment against bacterial infections. 3/10
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Terms, descriptions
CUI    C0002435
RussianMedical Subject Headings Russian D000560 L3337917preferred S3865398 Y АМДИНОЦИЛЛИН
RussianMedical Subject Headings Russian D000560 L0889792no S1093609 Y AMDINOTSILLIN
RussianMedical Subject Headings Russian D000560 L1519882no S1815791 Y FL 1060
RussianMedical Subject Headings Russian D000560 L1530342no S1826251 Y METSILLINAM
RussianMedical Subject Headings Russian D000560 L3357604no S3885089 Y МЕЦИЛЛИНАМ
Medical Subject Headings A0022457 AT208137823 An amidinopenicillanic acid derivative with broad spectrum antibacterial action.
NCI Thesaurus A12783579 AT198082527 A semisynthetic, broad spectrum beta-lactam penicillin with antibacterial activity. Amdinocillin specifically binds to and inactivates penicillin-binding protein 2 (PBP 2) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Given the fact that most beta-lactam penicillins bind almost exclusively to PBPs 1 and 3, amdinocillin is able to synergize with other penicillins in the treatment against bacterial infections.