C0002583 - A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0002583

Russian	Medical Subject Headings Russian	D000630	L3338141	preferred	S3865622	Y	АМИНОПТЕРИН
Russian	Medical Subject Headings Russian	D000630	L0889891	no	S1093708	Y	AMINOPTERIN
	Medical Subject Headings				A0022824	AT38135018	A folic acid derivative used as a rodenticide that has been shown to be teratogenic.
	(CPTSP) CRISP Thesaurus				A0473451	AT51225471	folic acid derivative used as a rodenticide that has been shown to be teratogenic.
	PDQ				A4343545	AT70657755	A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39141&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39141&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C235" NCI Thesaurus)
	NCI NCI Dictionary of Cancer Terms				A7568693	AT198065582	An anticancer drug that belongs to the family of drugs called antimetabolites.
	NCI Thesaurus				A7568693	AT198090101	A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)