C0002598 - a drug used to treat angina and arrythmia 1/10
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Terms, descriptions
CUI    C0002598
RussianMedical Subject Headings Russian D000638 L3338161preferred S3865642 Y АМИОДАРОН
RussianMedical Subject Headings Russian D000638 L0889897no S1093714 Y AMIODARON
Medical Subject Headings A0022870 AT199405480 An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
(CPTSP) CRISP Thesaurus A0473455 AT51224240 2-butyl-3-(3,5-diiodo-4-beta diethylaminoethoxybenzoyl) benzofuran; coronary vasodilator used as an antiarrhythmic; severe risk of pulmonary and hepatic toxicity via disruption of lysosomal function; also has amphiphilic phototoxin properties.
NCI Thesaurus A12783584 AT198094350 An iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.
CHV A18571123 AT130673094 a drug used to treat angina and arrythmia