C0002600 - A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0002600

Russian	Medical Subject Headings Russian	D000639	L3338168	preferred	S3865649	Y	АМИТРИПТИЛИН
Russian	Medical Subject Headings Russian	D000639	L0889898	no	S1093715	Y	AMITRIPTILIN
Russian	Medical Subject Headings Russian	D000639	L1545172	no	S1841081	Y	TEPERIN
Russian	Medical Subject Headings Russian	D000639	L1546250	no	S1842159	Y	TRIPTIZOL
Russian	Medical Subject Headings Russian	D000639	L3371578	no	S3899071	Y	ТЕПЕРИН
Russian	Medical Subject Headings Russian	D000639	L3372759	no	S3900252	Y	ТРИПТИЗОЛ
	Medical Subject Headings				A0013946	AT43116765	Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
	(CPTSP) CRISP Thesaurus				A0473460	AT51221393	tricyclic antidepressant with anticholinergic and sedative properties; it appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters; it also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
	NCI NCI Dictionary of Cancer Terms				A12792005	AT198119166	A drug that is used to treat depression and may be given to treat anxiety, sleep disorders, and pain. It is also being studied in an oral or gel form in the treatment of nerve pain caused by chemotherapy. Amitriptyline is a type of tricyclic antidepressant.
	NCI Thesaurus				A12792005	AT198119167	A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.