C0002699 - An aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death. This agent's cytotoxicity is maximal during the S phase of the cell cycle when topoisomerase levels are greatest. In addition, amsacrine may induce transcription of tumor promoter p53 protein and block p53 ubiquitination and proteasomal degradation, resulting in p53-dependent tumor cell apoptosis.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0002699

Russian	Medical Subject Headings Russian	D000677	L3338223	preferred	S3865704	Y	АМСАКРИН
Russian	Medical Subject Headings Russian	D000677	L0889929	no	S1093746	Y	AMSAKRIN
	Medical Subject Headings				A0023168	AT208145593	An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
	PDQ				A4344213	AT70646464	An aminoacridine derivative with potent antineoplastic properties. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks. This agent's cytotoxicity is maximal during the S phase of the cell cycle when topoisomerase levels are greatest. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39142&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39142&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C240" NCI Thesaurus)
	NCI Thesaurus				A7568709	AT198077941	An aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death. This agent's cytotoxicity is maximal during the S phase of the cell cycle when topoisomerase levels are greatest. In addition, amsacrine may induce transcription of tumor promoter p53 protein and block p53 ubiquitination and proteasomal degradation, resulting in p53-dependent tumor cell apoptosis.