C0002736 - A neurodegenerative disorder characterized by progressive degeneration of the motor neurons of the central nervous system. It results in weakness and atrophy of the muscles which leads to an inability to initiate and control voluntary movements. 1/10
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Terms, descriptions
CUI    C0002736
RussianMedical Subject Headings Russian D000690 L3369474preferred S3896964 Y СКЛЕРОЗ БОКОВОЙ АМИОТРОФИЧЕСКИЙ
RussianMedical Subject Headings Russian D000690 L0904620no S1108437 Y SKLEROZ BOKOVOI AMIOTROFICHESKII
RussianMedical Subject Headings Russian D000690 L1511768no S1807677 Y BOKOVOI SKLEROZ
RussianMedical Subject Headings Russian D000690 L1521386no S1817295 Y GERIGA BOLEZN'
RussianMedical Subject Headings Russian D000690 L1542000no S1837909 Y SHARKO BOLEZN'
RussianMDRRUS 10052889 L15744408no S19019828 Y БАС
RussianMDRRUS 10002026 L15766676no S19020772 N Боковой амиотрофический склероз
RussianMDRRUS 10002026 L15766676no S19020772 Y Боковой амиотрофический склероз
RussianMedical Subject Headings Russian D000690 L3341476no S3868957 Y БОКОВОЙ СКЛЕРОЗ
RussianMedical Subject Headings Russian D000690 L3344714no S3872193 Y ГЕРИГА БОЛЕЗНЬ
RussianMedical Subject Headings Russian D000690 L3376879no S3904372 Y ШАРКО БОЛЕЗНЬ
Medical Subject Headings A0023262 AT38140781 A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
(CPTSP) CRISP Thesaurus A0473531 AT51222394 progressive degeneration of the neurons that give rise to the corticospinal tract and of the motor cells of the brain stem and spinal cord, resulting in a deficit of upper and lower motor neurons.
MEDLINEPLUS A21145273 AT220106398

Amyotrophic lateral sclerosis (ALS) is a nervous system disease that attacks nerve cells called neurons in your brain and spinal cord. These neurons transmit messages from your brain and spinal cord to your voluntary muscles - the ones you can control, like in your arms and legs. At first, this causes mild muscle problems. Some people notice

  • Trouble walking or running
  • Trouble writing
  • Speech problems

Eventually, you lose your strength and cannot move. When muscles in your chest fail, you cannot breathe. A breathing machine can help, but most people with ALS die from respiratory failure.

The disease usually strikes between age 40 and 60. More men than women get it. No one knows what causes ALS. It can run in families, but usually it strikes at random. There is no cure. Medicines can relieve symptoms and, sometimes, prolong survival.

NIH: National Institute of Neurological Disorders and Stroke

NCI Thesaurus A7568717 AT213845483 A neurodegenerative disorder characterized by progressive degeneration of the motor neurons of the central nervous system. It results in weakness and atrophy of the muscles which leads to an inability to initiate and control voluntary movements.