C0003641 - A single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities. As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation. This agent also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0003641

Russian	Medical Subject Headings Russian	D007611	L3339284	preferred	S3866765	Y	АПРОТИНИН
Russian	Medical Subject Headings Russian	D007611	L0890371	no	S1094188	Y	APROTININ
Russian	Medical Subject Headings Russian	D007611	L1512128	no	S1808037	Y	BYCHII PANKREATICHESKII INGIBITOR TRIPSINA
Russian	Medical Subject Headings Russian	D007611	L1525657	no	S1821566	Y	KALLIKREIN-TRIPSINA INAKTIVATOR
Russian	Medical Subject Headings Russian	D007611	L1527229	no	S1823138	Y	KUNITTSA PANKREATICHESKII INGIBITOR TRIPSINA
Russian	Medical Subject Headings Russian	D007611	L1542013	no	S1837922	Y	SHCHELOCHNOI PANKREATICHESKII INGIBITOR TRIPSINA
Russian	Medical Subject Headings Russian	D007611	L1546247	no	S1842156	Y	TRIPSINA INGIBITOR KUNITZ PANKREATICHESKII
Russian	Medical Subject Headings Russian	D007611	L3342150	no	S3869632	Y	БЫЧИЙ ПАНКРЕАТИЧЕСКИЙ ИНГИБИТОР ТРИПСИНА
Russian	Medical Subject Headings Russian	D007611	L3351230	no	S3878714	Y	КАЛЛИКРЕИН-ТРИПСИНА ИНАКТИВАТОР
Russian	Medical Subject Headings Russian	D007611	L3354253	no	S3881736	Y	КУНИТЦА ПАНКРЕАТИЧЕСКИЙ ИНГИБИТОР ТРИПСИНА
Russian	Medical Subject Headings Russian	D007611	L3372753	no	S3900246	Y	ТРИПСИНА ИНГИБИТОР KUNITZ ПАНКРЕАТИЧЕСКИЙ
Russian	Medical Subject Headings Russian	D007611	L3377083	no	S3904576	Y	ЩЕЛОЧНОЙ ПАНКРЕАТИЧЕСКИЙ ИНГИБИТОР ТРИПСИНА
	Medical Subject Headings				A0025916	AT64677015	A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
	(CPTSP) CRISP Thesaurus				A0473868	AT51222001	single-chain polypeptide inhibitor of proteolytic enzymes including chymotrypsin, kallikrein, plasmin, and trypsin; used in the treatment of hemorrhage associated with raised plasma concentrations of plasmin; also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with extracorporeal circulation.
	PDQ				A11920276	AT70660636	A single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities. As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation. This agent also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=480388&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=480388&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47402" NCI Thesaurus)
	NCI Thesaurus				A15562771	AT198079896	A single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities. As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation. This agent also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis.