C0004482 - A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0004482

Russian	Medical Subject Headings Russian	D001379	L3337262	preferred	S3864743	Y	АЗАТИОПРИН
Russian	Medical Subject Headings Russian	D001379	L0890718	no	S1094535	Y	AZATIOPRIN
Russian	Medical Subject Headings Russian	D001379	L1524381	no	S1820290	Y	IMURAN
Russian	Medical Subject Headings Russian	D001379	L3350341	no	S3877826	Y	ИМУРАН
	Medical Subject Headings				A0028321	AT38145136	An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
	(CPTSP) CRISP Thesaurus				A0474279	AT51222118	immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis; possible carcinogen.
	CHV				A18590074	AT144404178	an immunosuppressive drug
	CHV				A18608680	AT144404179	an immunosuppressive drug
	CHV				A18664381	AT144404180	an immunosuppressive drug
	CHV				A18682861	AT144404181	an immunosuppressive drug
	NCI Thesaurus				A7568973	AT198078549	A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.