C0006050 - A serotype of botulinum toxins that has specificity for cleavage of SYNAPTOSOMAL-ASSOCIATED PROTEIN 25.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0006050

Russian	Medical Subject Headings Russian	D019274	L9624561	preferred	S12087089	Y	БОТУЛИНИЧЕСКИЕ ТОКСИНЫ ТИПА A
Russian	Medical Subject Headings Russian	D019274	L0891471	no	S1095288	Y	BOTULINICHESKII TOKSIN TIPA A
Russian	Medical Subject Headings Russian	D019274	L3341808	no	S3869290	Y	БОТУЛИНИЧЕСКИЙ ТОКСИН ТИПА A
Russian	Medical Subject Headings Russian	D019274	L9623757	no	S12085727	Y	BOTULINICHESKIE TOKSINY TIPA A
	NCI NCI Dictionary of Cancer Terms				A17691538	AT198072758	A drug used to treat certain medical conditions. These include severe underarm sweating and severe muscle spasms in the neck and shoulders. OnabotulinumtoxinA is also used to smooth wrinkles on the face. It is being studied in the treatment of pain in patients with skin leiomyomas (benign smooth muscle tumors) and other conditions. It is a form of a toxin made by the bacterium Clostridium botulinum..
	NCI NCI Dictionary of Cancer Terms				A17691538	AT198097294	A toxin made by the bacterium Clostridium botulinum. It can cause food poisoning. The drug Botox is a form of the toxin that can be used in small amounts to treat certain medical conditions. These include severe underarm sweating and severe muscle spasms in the neck and shoulders. Botulinum toxin type A is also used to smooth wrinkles on the face. It is being studied in the treatment of pain in patients with skin leiomyomas (benign smooth muscle tumors) and other conditions.
	NCI Thesaurus				A17691538	AT198134441	An injectable formulation of a neurotoxin derived through the fermentation of the Hall strain of Clostridium botulinum type A with neuromuscular transmission inhibitory and analgesic activities. Upon injection into the affected muscle, the heavy chain portion of botulinum toxin type A (BTX-A) binds to the cell membrane of the motor nerve and is internalized via endocytosis. Upon entry, the light chain portion of the toxin is activated and cleaves the protein SNAP-25, thereby preventing the fusion of acetylcholine (ACh)-containing synaptic vesicles with the cell membrane and, so, the release of ACh into the neuromuscular junction; subsequent binding of ACH to motor end-plate nicotinic acid receptors and ACh-mediated muscle contraction are thus blocked. In addition to ACh, BTX-A may inhibit the release of neuropeptides, such as substance P and glutamate, which may contribute to its analgesic activity.
	Medical Subject Headings				A18466424	AT127396513	A serotype of botulinum toxins that has specificity for cleavage of SYNAPTOSOMAL-ASSOCIATED PROTEIN 25.