C0006230 - A semisynthetic, ergot alkaloid with antiparkinson and lactation inhibitory activities. Bromocriptine selectively binds to and activates the postsynaptic dopamine D2-like receptors in the corpus striatum of the central nervous system (CNS). D2-like receptors are coupled to inhibitory G-proteins, which inhibit adenylyl cyclase, thereby preventing signal transduction mediated via cAMP and leading to an inhibitory effect on neurotransmission. This improves Parkinson symptoms, such as dyskinesia. Bromocriptine also has an inhibitory effect on the anterior pituitary gland, which results in blockage of prolactin secretion, thereby suppressing lactation. 2/10
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Terms, descriptions
CUI    C0006230
RussianMedical Subject Headings Russian D001971 L3341906preferred S3869388 Y БРОМОКРИПТИН
RussianMedical Subject Headings Russian D001971 L0891523no S1095340 Y BROMOKRIPTIN
RussianMedical Subject Headings Russian D001971 L1507110no S1803019 Y 2-BROMOERGOKRIPTIN
RussianMedical Subject Headings Russian D001971 L1535639no S1831548 Y PARLODEL
RussianMedical Subject Headings Russian D001971 L3334799no S3862305 Y 2-БРОМОЭРГОКРИПТИН
RussianMedical Subject Headings Russian D001971 L3362499no S3889973 Y ПАРЛОДЕЛ
Medical Subject Headings A0032792 AT38149662 A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.
(CPTSP) CRISP Thesaurus A0475068 AT32351117 D2 dopamine agonist used as a prolactin inhibitor.
NCI Thesaurus A12787952 AT197983395 A semisynthetic, ergot alkaloid with antiparkinson and lactation inhibitory activities. Bromocriptine selectively binds to and activates the postsynaptic dopamine D2-like receptors in the corpus striatum of the central nervous system (CNS). D2-like receptors are coupled to inhibitory G-proteins, which inhibit adenylyl cyclase, thereby preventing signal transduction mediated via cAMP and leading to an inhibitory effect on neurotransmission. This improves Parkinson symptoms, such as dyskinesia. Bromocriptine also has an inhibitory effect on the anterior pituitary gland, which results in blockage of prolactin secretion, thereby suppressing lactation.