C0006463 - A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0006463

Russian	Medical Subject Headings Russian	D002066	L3357719	preferred	S3885203	Y	МИЕЛОСАН
Russian	Medical Subject Headings Russian	D002066	L0899244	no	S1103061	Y	MIELOSAN
Russian	Medical Subject Headings Russian	D002066	L1512094	no	S1808003	Y	BUSUL'FAN
Russian	Medical Subject Headings Russian	D002066	L3342085	no	S3869567	Y	БУСУЛЬФАН
	Medical Subject Headings				A0033415	AT53896094	An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
	(CPTSP) CRISP Thesaurus				A0475165	AT51222610	alkylating agent having a selective immunosuppressive effect on bone marrow; has been used in the palliative treatment of chronic myeloid leukemia.
	PDQ				A4343571	AT70658023	A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41947&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41947&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C321" NCI Thesaurus)
	NCI NCI Dictionary of Cancer Terms				A7569265	AT198103387	An anticancer drug that belongs to the family of drugs called alkylating agents.
	NCI Thesaurus				A7569265	AT198115722	A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)