C0007047 - The (15S)-15 methyl analogue of naturally occurring prostaglandin F2 alpha (PGF2 alpha) with oxytocic activity. Mimicking endogenous PGF2 alpha, carboprost activates prostaglandin F receptor, a G-protein coupled receptor, on smooth muscle cells, thereby resulting in smooth muscle contractions. When administered intramuscularly on gravid subjects, this agent induces myometrium contractions, thereby initiating luteolysis and consequently parturition. Furthermore, carboprost's action on vascular smooth muscle and gastrointestinal tract sphincters leads to raised blood pressure and induces vomiting or diarrhea, respectively. 2/10
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Terms, descriptions
CUI    C0007047
RussianMedical Subject Headings Russian D002260 L3351588preferred S3879072 Y КАРБОПРОСТ
RussianMedical Subject Headings Russian D002260 L0896279no S1100096 Y KARBOPROST
RussianMedical Subject Headings Russian D002260 L1507034no S1802943 Y 15-METILPROSTAGLANDIN F2 AL'FA
RussianMedical Subject Headings Russian D002260 L1507036no S1802945 Y 15-METILPROSTAGLANDINA F2 AL'FA METILOVYI EFIR
RussianMedical Subject Headings Russian D002260 L1530230no S1826139 Y METILDINOPROST
RussianMedical Subject Headings Russian D002260 L3334732no S3862185 Y 15-МЕТИЛПРОСТАГЛАНДИН F2 АЛЬФА
RussianMedical Subject Headings Russian D002260 L3334734no S3862187 Y 15-МЕТИЛПРОСТАГЛАНДИНА F2 АЛЬФА МЕТИЛОВЫЙ ЭФИР
RussianMedical Subject Headings Russian D002260 L3357411no S3884896 Y МЕТИЛДИНОПРОСТ
Medical Subject Headings A0034904 AT53894298 A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of PREGNANCY.
NCI Thesaurus A12802071 AT198131414 The (15S)-15 methyl analogue of naturally occurring prostaglandin F2 alpha (PGF2 alpha) with oxytocic activity. Mimicking endogenous PGF2 alpha, carboprost activates prostaglandin F receptor, a G-protein coupled receptor, on smooth muscle cells, thereby resulting in smooth muscle contractions. When administered intramuscularly on gravid subjects, this agent induces myometrium contractions, thereby initiating luteolysis and consequently parturition. Furthermore, carboprost's action on vascular smooth muscle and gastrointestinal tract sphincters leads to raised blood pressure and induces vomiting or diarrhea, respectively.