C0007570 - An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0007570

Russian	Medical Subject Headings Russian	D002446	L3375969	preferred	S3903461	Y	ЦЕЛИАКИЯ
Russian	Medical Subject Headings Russian	D002446	L0906407	no	S1110224	Y	TSELIAKIIA
Russian	Medical Subject Headings Russian	D002446	L1511861	no	S1807770	Y	BOLEZN' GLIUTENOVAIA
Russian	Medical Subject Headings Russian	D002446	L1521997	no	S1817906	Y	GLIUTENOVAIA ENTEROPATIIA
Russian	Medical Subject Headings Russian	D002446	L1543111	no	S1839020	Y	SPRU
Russian	MDRRUS	10018461	L15712403	no	S19029157	Y	Глютензависимая энтеропатия
Russian	MDRRUS	10029525	L15715230	no	S19051541	Y	Нетропическая спру
Russian	MDRRUS	10007864	L15723384	no	S19029159	Y	Глютенчувствительная целиакия
Russian	MDRRUS	10009839	L15731432	no	S19092780	N	Целиакия
Russian	MDRRUS	10009839	L15731432	no	S19092780	Y	Целиакия
Russian	MDRRUS	10058248	L15764662	no	S19092778	Y	Целиакия спру
Russian	MDRRUS	10018458	L15778706	no	S19029158	Y	Глютеновая энтеропатия
Russian	MDRRUS	10007865	L15786580	no	S19092779	Y	Целиакия-спру
Russian	Medical Subject Headings Russian	D002446	L3341510	no	S3868992	Y	БОЛЕЗНЬ ГЛЮТЕНОВАЯ
Russian	Medical Subject Headings Russian	D002446	L3346045	no	S3873528	Y	ГЛЮТЕНОВАЯ ЭНТЕРОПАТИЯ
Russian	Medical Subject Headings Russian	D002446	L3370345	no	S3897835	Y	СПРУ
	Medical Subject Headings				A0036279	AT127396928	A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.
	(CPTSP) CRISP Thesaurus				A0475635	AT51223642	disease occurring in children and adults characterized by sensitivity to gluten, with chronic inflammation and atrophy of the mucosa of the upper small intestine; manifestations include diarrhea, malabsorption, steatorrhea, and nutritional and vitamin deficiencies.
	Medical Subject Headings Czech				A13061797	AT231378362	Onemocnění způsobující poruchu střevního vstřebávání (primární malabsorpční syndrom). Jeho podstatou je nesnášenlivost glutenu, resp. jeho složky gliadinu na imunologickém podkladě, vyvolávající zánětlivé postižení v oblasti tenkého střeva (zejm. jejuna). Histopatologicky je atrofie klků, lymfoplasmocytární infiltrace, poruchy enzymů. Onemocnění začíná častěji v dětství, ale výskyt v dospělosti není vůbec neobvyklý a uplatňují se u něj dědičné vlivy (některé HLA antigeny - zejm. HLA-DQ2). Příznaky malabsorpce (průjmy, nedostatek živin z porušeného vstřebávání, anemie, kostní změny, neuropatie, hubnutí aj.) se objevují po požití potravin obsahujících lepek a mizí po jeho vyloučení ze stravy. Časté a mnohdy převládající však jsou příznaky extraintestinální, zejm. kloubní, kožní (Duhringova herpetitformní dermatitida). V diagnóze je důležitá enterobiopsie (atrofie sliznice, zánětlivá infiltrace, enzymatické změny), vyšetření některých protilátek (proti gliadinu, endomyosinu, tkáňové transglutamináze) a vyšetření malabsorpce (např. xylosový test). Základem léčby je dieta s vyloučením lepku (tj. zákaz potravin z pšeničné a žitné mouky), jejíž dodržování výrazně zlepšuje prognózu. Je možné jej nahradit moukou kukuřičnou, sójou, rýží, bramborami. Karence se léčí substitucí, v těžších případech se podávají přechodně kortikoidy. Průběh choroby je kolísavý a různě těžký, obv. chronický s možnými relapsy i po expozici malému množství glutenu. Některé formy onemocnění mohou mít lehčí průběh a unikat diagnóze. U části pacientů se objevují i některé další poruchy imunitního systému (diabetes mellitus 1. typu, SLE, autoimunitní tyroiditida aj.); je častější výskyt malignit (lymfomy střeva i karcinomy) (cit. Velký lékařský slovník online, 2017 http://lekarske.slovniky.cz)
	MEDLINEPLUS				A21144506	AT230154344	Celiac disease is an immune disease in which people can't eat gluten because it will damage their small intestine. If you have celiac disease and eat foods with gluten, your immune system responds by damaging the small intestine. Gluten is a protein found in wheat, rye, and barley. It may also be in other products like vitamins and supplements, hair and skin products, toothpastes, and lip balm. Celiac disease affects each person differently. Symptoms may occur in the digestive system, or in other parts of the body. One person might have diarrhea and abdominal pain, while another person may be irritable or depressed. Irritability is one of the most common symptoms in children. Some people have no symptoms. Celiac disease is genetic. Blood tests can help your doctor diagnose the disease. Your doctor may also need to examine a small piece of tissue from your small intestine. Treatment is a diet free of gluten. NIH: National Institute of Diabetes and Digestive and Kidney Diseases
	HPO				A24668654	AT206291272	Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. Clinical manifestations of CD are highly variable and include both gastrointestinal and non-gastrointestinal features. The hallmark of CD is an immune-mediated enteropathy. This term is included because the occurence of CD is seen as a feature of a number of other diseases. [HPO:probinson, pmid:23681421]
	NCI NCI Dictionary of Cancer Terms				A7569404	AT198041568	A digestive disease that is caused by an immune response to a protein called gluten, which is found in wheat, rye, barley, and oats. Celiac disease damages the lining of the small intestine and interferes with the absorption of nutrients from food. A person with celiac disease may become malnourished no matter how much food is consumed.
	NCI Thesaurus				A7569404	AT198078276	An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.