C0008161 - A synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system. 1/10
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Terms, descriptions
CUI    C0008161
RussianMedical Subject Headings Russian D002697 L3375303preferred S3902795 Y ХЛОРАЛГИДРАТ
RussianMedical Subject Headings Russian D002697 L0896612no S1100429 Y KHLORALGIDRAT
Medical Subject Headings A0037973 AT73529980 A hypnotic and sedative used in the treatment of INSOMNIA.
(CPTSP) CRISP Thesaurus A0475930 AT51225325 hypnotic and sedative used in the treatment of insomnia; the safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments; chemical formula CCL3CH(OH)2.
NCI Thesaurus A7569509 AT198115449 A synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system.