C0008168 - A semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blocks peptide bond formation. As a result bacterial protein synthesis is blocked and impede bacterial cell proliferation.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0008168

Russian	Medical Subject Headings Russian	D002701	L3375308	preferred	S3902801	Y	ХЛОРАМФЕНИКОЛ
Russian	Medical Subject Headings Russian	D002701	L0896615	no	S1100432	Y	KHLORAMFENIKOL
Russian	Medical Subject Headings Russian	D002701	L1521969	no	S1817878	Y	GLIUKOKHLORAL
Russian	Medical Subject Headings Russian	D002701	L1526099	no	S1822008	Y	KHLORANFENIKOL
Russian	Medical Subject Headings Russian	D002701	L1526590	no	S1822499	Y	KLORAMFENIKOL
Russian	Medical Subject Headings Russian	D002701	L1528356	no	S1824265	Y	LEVOMITSETIN
Russian	Medical Subject Headings Russian	D002701	L3346033	no	S3873516	Y	ГЛЮКОХЛОРАЛ
Russian	Medical Subject Headings Russian	D002701	L3352577	no	S3880061	Y	КЛОРАМФЕНИКОЛ
Russian	Medical Subject Headings Russian	D002701	L3354554	no	S3882038	Y	ЛЕВОМИЦЕТИН
Russian	Medical Subject Headings Russian	D002701	L3375313	no	S3902805	Y	ХЛОРАНФЕНИКОЛ
	Medical Subject Headings				A0037996	AT38141212	An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
	(CPTSP) CRISP Thesaurus				A0475940	AT51220597	antibiotic first isolated from cultures of Streptomyces venequelae but now produced synthetically; has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered; it acts by interfering with bacterial protein synthesis and is mainly bacteriostatic.
	NCI Thesaurus				A7569512	AT198103655	A semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blocks peptide bond formation. As a result bacterial protein synthesis is blocked and impede bacterial cell proliferation.