C0008196 - A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0008196

Russian	Medical Subject Headings Russian	D002710	L3375319	preferred	S3902812	Y	ХЛОРГЕКСИДИН
Russian	Medical Subject Headings Russian	D002710	L0896635	no	S1100452	Y	KHLORGEKSIDIN
	Medical Subject Headings				A0038058	AT38134652	A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
	(CPTSP) CRISP Thesaurus				A0475956	AT51220504	disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
	PDQ				A4343592	AT70652873	A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41544&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41544&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C364" NCI Thesaurus)
	NCI Thesaurus				A7569517	AT198128393	A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.