C0008269 - A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0008269

Russian	Medical Subject Headings Russian	D002738	L3375391	preferred	S3902884	Y	ХЛОРОХИН
Russian	Medical Subject Headings Russian	D002738	L0896661	no	S1100478	Y	KHLOROKHIN
Russian	Medical Subject Headings Russian	D002738	L1526051	no	S1821960	Y	KHINGAMIN
Russian	Medical Subject Headings Russian	D002738	L3375186	no	S3902679	Y	ХИНГАМИН
	Medical Subject Headings				A0038279	AT38146847	The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
	(CPTSP) CRISP Thesaurus				A0475992	AT51224448	antiamebic and antimalarial; chloroquine phosphate is also listed by USP as a suppressant of lupus erythematosus.
	NCI Thesaurus				A12802140	AT198106707	A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.