C0009262 - An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflammatory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0009262

Russian	Medical Subject Headings Russian	D003078	L3352965	preferred	S3880449	Y	КОЛХИЦИН
Russian	Medical Subject Headings Russian	D003078	L0897194	no	S1101011	Y	KOLKHITSIN
	Medical Subject Headings				A0040700	AT38136394	A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).
	(CPTSP) CRISP Thesaurus				A0476461	AT51224080	inhibits tubulin-tubulin binding and thus destabilizes microtubules; used to block mitosis, axonal transport, and other microtubule dependent cellular functions in vitro, and clinically to treat gout.
	(SPN) Standard Product Nomenclature				A0887855	AT20133585	A general purpose reagent is a chemical reagent that has general laboratory application, that is used to collect, prepare, and examine specimens from the human body for diagnostic histopathology, cytology, and hematology, and that is not labeled or otherwise intended for a specific diagnostic application. General purpose reagents include cytological preservatives, decalcifying reagents, fixatives and adhesives, tissue processing reagents, isotonic solutions, and pH buffers.
	CHV				A18553527	AT130671738	a drug used to prevent or treat attacks of gout
	CHV				A18646452	AT130671739	a drug used to prevent or treat attacks of gout
	PDQ				A4343604	AT70657830	An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activity. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflammatory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39188&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39188&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C385" NCI Thesaurus)
	NCI NCI Dictionary of Cancer Terms				A7569665	AT197955525	A drug used to treat gout (inflamed joints caused by a buildup of uric acid). It comes from the crocus plant Colchicum autumnale. Colchicine blocks cell division and the movement of certain immune cells to areas that are inflamed. It is a type of alkaloid and a type of mitotic inhibitor.
	NCI Thesaurus				A7569665	AT198116111	An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflammatory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals.