C0017351 - Genes and gene segments encoding the IMMUNOGLOBULIN HEAVY CHAINS. Gene segments of the heavy chain genes are symbolized V (variable), D (diversity), J (joining), and C (constant).

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0017351

Russian	Medical Subject Headings Russian	D050438	L5697110	preferred	S6530147	Y	ГЕНЫ ТЯЖЕЛЫХ ЦЕПЕЙ ИММУНОГЛОБУЛИНА
Russian	Medical Subject Headings Russian	D050438	L5697324	no	S6530361	Y	ИММУНОГЛОБУЛИНА ТЯЖЕЛЫХ ЦЕПЕЙ ГЕНЫ
Russian	Medical Subject Headings Russian	D050438	L6967548	no	S8106376	Y	GENY TIAZHELYKH TSEPEI IMMUNOGLOBULINA
Russian	Medical Subject Headings Russian	D050438	L6971482	no	S8106796	Y	IMMUNOGLOBULINA TIAZHELYKH TSEPEI GENY
	NCI Thesaurus				A7600731	AT198127544	This region represents the germline organization of the immunoglobulin heavy chain locus. The locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)
	Medical Subject Headings				A8395222	AT53895578	Genes and gene segments encoding the IMMUNOGLOBULIN HEAVY CHAINS. Gene segments of the heavy chain genes are symbolized V (variable), D (diversity), J (joining), and C (constant).