C0021027 - <p>immune globulin, NOS</p> 4/10
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Terms, descriptions
CUI    C0021027
RussianMedical Subject Headings Russian D007136 L3350196preferred S3877684 Y ИММУНОГЛОБУЛИНЫ
RussianMedical Subject Headings Russian D007136 L0895629no S1099446 Y IMMUNOGLOBULINY
RussianMedical Subject Headings Russian D007136 L1522005no S1817914 Y GLOBULINY IMMUNNYE
RussianMedical Subject Headings Russian D007136 L1524276no S1820185 Y IMMUNNYE GLOBULINY
RussianMedical Subject Headings Russian D007136 L3345866no S3873349 Y ГЛОБУЛИНЫ ИММУННЫЕ
RussianMedical Subject Headings Russian D007136 L3350139no S3877624 Y ИММУННЫЕ ГЛОБУЛИНЫ
Medical Subject Headings A0072488 AT53896457 Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
(CPTSP) CRISP Thesaurus A0481605 AT51219642 glycoproteins found in the blood that function as antibodies; the basic structure is a y shaped molecule consisting of two light polypeptide chains and two heavy polypeptide chains linked by disulfide bonds.
(CPTSP) CRISP Thesaurus A1196115 AT51225178 there are two types of polypeptide chains responsible for the biological and immunological properties of the different immunoglobulins, the heavy chain and the light chain; they are linked by covalent and non-covalent forces to give a four-chain Y-shaped structure based on pairs of identical heavy and light chains; each chain consists of a variable region and a constant region which are coded for by different genes; some immunoglobulin classes occur as polymers of this basic monomer.
Medical Subject Headings Czech A13049729 AT231366092 Protilátka, termín zdůrazňuje její bílkovinnou povahu globin. Imunoglobuliny jsou vytvářeny plasmatickými buňkami vznikajícími z B lymfocytů po setkání s cizorodým materiálem - antigenem, proti kterému je následně specializován příslušný i. Jeho funkcí je ochrana proti infekci, zneškodňování toxinů, protektivní protilátka, imunologický dozor nad vlastními tkáněmi organismu aj. Přítomnosti i. v lidském organismu se využívá jako průkazu infekce. Základní strukturu molekuly i. tvoří 2 těžké H a 2 lehké řetězce L, které jsou spojeny disulfidickými můstky. N-konce řetězců představují variabilní část molekuly, která váže antigen fragment Fab, fragment Fc, který obsahuje C-konec molekuly, zprostředkovává její biologickou aktivitu. Existuje pět tříd imunoglobulinů M, G, A, E, D. (cit. Velký lékařský slovník online, 2017 http://lekarske.slovniky.cz)
PDQ A4345750 AT70658044 A preparation of plasma proteins derived from the pooled plasma of adult donors. Largely comprised of IgG antibodies, therapeutic immune globulin provides passive immunization by increasing the recipient's serum levels of circulating antibodies. IgG antibodies have multiple functions, including binding to and neutralizing bacterial toxins; opsonization of pathogens; activation of complement; and suppression of pathogenic cytokines and phagocytes through binding to CD5, interleukin-1a (IL-1a), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and T-cell receptors. Therapeutic immune globulin may diminish pathogenic mechanisms in some autoimmune diseases by binding to and inhibiting the activity of autoantibodies. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40109&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40109&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2701" NCI Thesaurus)
NCI Thesaurus A7571320 AT197995426 Any of the structurally related glycoproteins that function as antibodies. They are divided into five classes (IGA, IGD, IGE, IGG, IGM) on the basis of structure and biological activity.
NCI NCI Dictionary of Cancer Terms A7571320 AT198131073 A protein that acts as an antibody. Immunoglobulins are made by B cells and plasma cells. An Ig is a type of glycoprotein with two heavy chains and two light chains.
HL7V3.0 A8318253 AT144243744

immune globulin, NOS