C0026769 - An autoimmune demyelinating disease characterized by a relapsing-remitting or progressive pattern of central nervous system impairment.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0026769

Russian	Medical Subject Headings Russian	D009103	L3369480	preferred	S3896972	Y	СКЛЕРОЗ РАССЕЯННЫЙ
Russian	Medical Subject Headings Russian	D009103	L0904621	no	S1108438	Y	SKLEROZ RASSEIANNYI
Russian	Medical Subject Headings Russian	D009103	L1542637	no	S1838546	Y	SKLEROZ MNOZHESTVENNYI
Russian	MDRRUS	10013451	L15736818	no	S19047519	Y	Множественный склероз
Russian	MDRRUS	10039720	L15751348	no	S19075133	Y	Рассеянный склероз (РС)
Russian	MDRRUS	10028053	L15762330	no	S19073879	Y	РС
Russian	MDRRUS	10028245	L15773341	no	S19075138	N	Рассеянный склероз
Russian	MDRRUS	10028245	L15773341	no	S19075138	Y	Рассеянный склероз
Russian	Medical Subject Headings Russian	D009103	L3369476	no	S3896968	Y	СКЛЕРОЗ МНОЖЕСТВЕННЫЙ
	Medical Subject Headings				A0088571	AT43116098	An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
	(CPTSP) CRISP Thesaurus				A0484255	AT51223530	chronic disease characterized by presence of numerous areas of demyelination in the central nervous system with symptoms such as weakness, incoordination, paresthesis, and speech disturbances; the etiology is unknown.
	Medical Subject Headings Czech				A13057128	AT204250739	Chronické onemocnění CNS charakterizované demyelinizací. Postihuje osoby spíše mladšího a středního věku. Příčina onemocnění není známa, k teoriím patří účast neznámého viru a autoimunitní poškození, existuje asociace s některými antigeny HLA systému. Příznaky r. s. závisejí na poškozeném místě v nervové soustavě a mohou být velmi pestré - spinální, cerebrální, cerebelární poruchy chůze, citlivosti, řeči, močení, ataxie, obrny aj.. Úvodním příznakem často bývá retrobulbární neuritida zrakového nervu. Mohou být i psychické příznaky např. deprese, ale i euforie. Průběh nemoci je kolísavý, střídají se období klidu s náhlými zhoršeními. Ta jsou často vyprovokována i běžným onemocněním. Těžký průběh nemoci může vést až k invaliditě. V diagnostice se uplatňuje vyšetření likvoru, evokované potenciály, zobrazovací metody. Zkouší se řada léčebných postupů, ale žádný zatím nedokáže nemoc vyléčit. Používají se např. kortikoidy, imunosupresiva, interferon, významná je i fyzioterapie a rehabilitace. (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ )
	MSHNOR				A20201986	AT221328789	En autoimmun sykdom som først og fremst rammer unge voksne og som kjennetegnes ved nedbryting av myelin i sentralnervesystemet. Patologiske funn omfatter blant annet flere skarpt avgrensede områder av demyelinisering i sentralnervesystemets hvite substans. Kliniske manifestasjoner inkluderer synstap, ekstraokulære bevegelsesforstyrrelser, parestesier, tap av følelse, svakhet, dysartri, spastisitet, ataksi og blæredysfunksjon. Det vanlige mønsteret består av tilbakevendende angrep etterfulgt av delvis tilfriskning (se relapserende-remitterende multippel sklerose), men det finnes også akutt oppblussende og kronisk progressive former (se kronisk progressiv multippel sklerose).
	MEDLINEPLUS				A21143126	AT203073596	Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the myelin sheath, the material that surrounds and protects your nerve cells. This damage slows down or blocks messages between your brain and your body, leading to the symptoms of MS. They can include Visual disturbances Muscle weakness Trouble with coordination and balance Sensations such as numbness, prickling, or "pins and needles" Thinking and memory problems No one knows what causes MS. It may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. Multiple sclerosis affects women more than men. It often begins between the ages of 20 and 40. Usually, the disease is mild, but some people lose the ability to write, speak, or walk. There is no single test for MS. Doctors use a medical history, physical exam, neurological exam, MRI, and other tests to diagnose it. There is no cure for MS, but medicines may slow it down and help control symptoms. Physical and occupational therapy may also help. NIH: National Institute of Neurological Disorders and Stroke
	NCI NCI Dictionary of Cancer Terms				A7572279	AT197992510	A disorder of the central nervous system marked by weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control. Multiple sclerosis is thought to be an autoimmune disease in which the body's immune system destroys myelin. Myelin is a substance that contains both protein and fat (lipid), serving as a nerve insulator and helping in the transmission of nerve signals.
	NCI Thesaurus				A7572279	AT197992511	A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.
	NCI National Institute of Child Health and Human Development				A7572279	AT210367955	An autoimmune demyelinating disease characterized by a relapsing-remitting or progressive pattern of central nervous system impairment.