C0030567 - A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression. 1/10
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CUI    C0030567
RussianMedical Subject Headings Russian D010300 L3362489preferred S3889963 Y ПАРКИНСОНА БОЛЕЗНЬ
RussianMedical Subject Headings Russian D010300 L0901352no S1105169 Y PARKINSONA BOLEZN'
RussianMedical Subject Headings Russian D010300 L1535445no S1831354 Y PARALICH DROZHATEL'NYI
RussianMDRRUS 10034007 L15722367no S19021091 Y Болезнь Паркинсона БДУ
RussianMDRRUS 10034004 L15724403no S19036879 Y Идиопатический синдром паркинсонизма
RussianMDRRUS 10013113 L15762978no S19079127 Y Симптомы болезни Паркинсона
RussianMDRRUS 10033565 L15768114no S19032418 N Дрожательный паралич
RussianMDRRUS 10033801 L15768114no S19032418 Y Дрожательный паралич
RussianMDRRUS 10034008 L15784977no S19079530 Y Синдром Паркинсона
RussianMDRRUS 10061536 L15788577no S19021094 N Болезнь Паркинсона
RussianMDRRUS 10061536 L15788577no S19021094 Y Болезнь Паркинсона
RussianMDRRUS 10042832 L15793662no S19062316 Y Паркинсона синдром
RussianMedical Subject Headings Russian D010300 L3362365no S3889832 Y ПАРАЛИЧ ДРОЖАТЕЛЬНЫЙ
Medical Subject Headings A0097907 AT38139281 A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
(CPTSP) CRISP Thesaurus A0445180 AT51224033 progressive, degenerative disorder of the nervous system characterized by tremors, rigidity, bradykinesia, postural instability, and gait abnormalities; caused by a loss of neurons and a decrease of dopamine in the basal ganglia.
Medical Subject Headings Czech A13062888 AT195260876 Onemocnění nervového systému bazálních ganglií mozku, jehož nápadným příznakem je převážně klidový třes (tremor). Současně je zvýšená svalová ztuhlost (rigidita), pohybová chudost (hypokineze), maskovitý obličej, změněná řeč a chůze (s nebezpečím pádu). Často bývají rovněž vegetativní příznaky (zácpa, poruchy spánku) či psychické obtíže. Kromě neurologického postižení může být přítomna podkorová demence, zpomalení psychických procesů, deprese. Úbytek kognitivních funkcí je spíše pomalý. Morfologicky lze nalézt zejm. Lewyho tělíska, bývají rovněž depigmentace substantia nigra. Příčina není známa, na vzniku se podílí např. oxidační poškození buněk. Podstatou je porucha metabolismu některých látek v mozku (nedostatek dopaminu v bazálních gangliích a relativní převaha acetylcholinu). V léčbě se používají antiparkinsonika. Ochranný vliv na zbylé buňky produkující dopamin se někdy připisuje selegilinu. Zkouší se transplantace nervových buněk lidského zárodku, které by nahradily nedostatečnou tvorbu dopaminu. (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ )
MSHNOR A20202117 AT221319644 En progressiv, degenerativ nevrologisk sykdom som er karakterisert ved tremor (skjelving) som er maksimal ved hvile, retropulsjon (dvs. en tendens til å falle bakover), muskelstivhet, fremoverbøyd holdning, langsomhet i frivillige bevegelser og et maskeliknende ansiktsuttrykk. Patologiske kjennetegn inkluderer tap av melaninnevroner i substantia nigra og andre pigmenterte kjerner i hjernestammen. Lewylegemer er til stede i substantia nigra og locus coeruleus, men kan også finnes ved en beslektet tilstand (sykdom med lewylegemer) preget av demens i kombinasjon med varierende grad av parkinsonisme.
MEDLINEPLUS A21143565 AT220104740

Parkinson's disease (PD) is a type of movement disorder. It happens when nerve cells in the brain don't produce enough of a brain chemical called dopamine. Sometimes it is genetic, but most cases do not seem to run in families. Exposure to chemicals in the environment might play a role.

Symptoms begin gradually, often on one side of the body. Later they affect both sides. They include

  • Trembling of hands, arms, legs, jaw and face
  • Stiffness of the arms, legs and trunk
  • Slowness of movement
  • Poor balance and coordination

As symptoms get worse, people with the disease may have trouble walking, talking, or doing simple tasks. They may also have problems such as depression, sleep problems, or trouble chewing, swallowing, or speaking.

There is no lab test for PD, so it can be difficult to diagnose. Doctors use a medical history and a neurological examination to diagnose it.

PD usually begins around age 60, but it can start earlier. It is more common in men than in women. There is no cure for PD. A variety of medicines sometimes help symptoms dramatically. Surgery and deep brain stimulation (DBS) can help severe cases. With DBS, electrodes are surgically implanted in the brain. They send electrical pulses to stimulate the parts of the brain that control movement.

NIH: National Institute of Neurological Disorders and Stroke

(PSY) Psychological Index Terms A7560860 AT46115498 A disease characterized as a progressive motor disability manifested by tremors, shaking, muscular rigidity, and lack of postural reflexes.
NCI NCI Dictionary of Cancer Terms A7572839 AT197979411 A progressive disorder of the nervous system marked by muscle tremors, muscle rigidity, decreased mobility, stooped posture, slow voluntary movements, and a mask-like facial expression.
NCI Thesaurus A7572839 AT198090426 A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.