C0033209 - A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0033209

Russian	Medical Subject Headings Russian	D011339	L3365241	preferred	S3892724	Y	ПРОБЕНЕЦИД
Russian	Medical Subject Headings Russian	D011339	L0902686	no	S1106503	Y	PROBENETSID
Russian	Medical Subject Headings Russian	D011339	L1537227	no	S1833136	Y	PROBETSID
Russian	Medical Subject Headings Russian	D011339	L3365242	no	S3892725	Y	ПРОБЕЦИД
	Medical Subject Headings				A0105105	AT38146063	The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
	(CPTSP) CRISP Thesaurus				A0487278	AT32351462	USP lists as a uricosuric, an agent that promotes uric acid secretion in urine.
	PDQ				A4343826	AT70651256	A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40223&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40223&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C772" NCI Thesaurus)
	(PSY) Psychological Index Terms				A7561020	AT46116873	Agent that promotes the urinary excretion of uric acid.
	NCI NCI Dictionary of Cancer Terms				A7573172	AT198059705	A drug that is used to treat gout and is used together with some antibiotics to make them work better. It is being studied in the treatment of cancer. It belongs to the family of drugs called antibiotic therapy adjuncts.
	NCI Thesaurus				A7573172	AT198108920	A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration.