C0039601 - A synthetic form of the endogenous androgenic steroid testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative.

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0039601

Russian	Medical Subject Headings Russian	D013739	L3371703	preferred	S3899196	Y	ТЕСТОСТЕРОН
Russian	Medical Subject Headings Russian	D013739	L0905745	no	S1109562	Y	TESTOSTERON
	Medical Subject Headings				A0124357	AT53895662	A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
	(CPTSP) CRISP Thesaurus				A0490218	AT51219690	major androgenic hormone produced by the Leydig cells of the testes.
	PDQ				A11920074	AT70646581	A synthetic form of the endogenous androgenic steroid testosterone. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative. This agent and its derivatives promote the maintenance of male sex characteristics. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42926&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42926&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C862" NCI Thesaurus)
	Medical Subject Headings Czech				A13050636	AT231362340	Mužský pohlavní steroidní hormon (androgen), vzniká ve varlatech v Leydigových buňkách. Tvorba t. je řízena hypofyzárním hormonem LH. V době vývoje plodu má vliv na vznik mužských pohlavních orgánů (penis, šourek aj.). Později jeho tvorba stoupá opět až v pubertě, kdy se t. podílí na vývoji sekundárních pohlavních znaků (růst, vývoj svalstva, hrubší kůže, změna hlasu, psychické změny, vývoj ochlupení i změna hranice vlasů na hlavě aj.). Je nezbytný pro správnou tvorbu spermií. V citlivých tkáních se mění (redukuje) na účinnější dihydrotestosteron. Je možné jej podat v lékové formě, stejně jako je možné některými léky (antiandrogeny) tlumit jeho účinky. (cit. Velký lékařský slovník online, 2017 http://lekarske.slovniky.cz)
	NCI NCI Dictionary of Cancer Terms				A7574028	AT198114822	A hormone made mainly in the testes (part of the male reproductive system). It is needed to develop and maintain male sex characteristics, such as facial hair, deep voice, and muscle growth. Testosterone may also be made in the laboratory and is used to treat certain medical conditions.
	NCI Thesaurus				A7664483	AT198036562	A synthetic form of the endogenous androgenic steroid testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative.