293,031 терминов и синонимов из MeSH и LOINC
Lang Dictionary CODE | LUI | preferred no |
SUI | preference Yes / No |
Terms, descriptions |
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CUI C0085173 | |||||||
Russian | Medical Subject Headings Russian | D016593 | L3371690 | preferred | S3899183 | Y | ТЕРФЕНАДИН |
Russian | Medical Subject Headings Russian | D016593 | L0905723 | no | S1109540 | Y | TERFENADIN |
Medical Subject Headings | A0124103 | AT73509034 | A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME. | ||||
NCI Thesaurus | A7574017 | AT198017100 | A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked, thereby preventing the triggering of pro-inflammatory pathways. |