C0524891 - This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. (from LocusLink)

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Lang Dictionary CODE			LUI	preferred no	SUI	preference Yes / No	Terms, descriptions
							CUI C0524891

Russian	Medical Subject Headings Russian	D019674	L3344463	preferred	S3871951	Y	ГЕНЫ T-КЛЕТОЧНЫХ РЕЦЕПТОРОВ БЕТА
Russian	Medical Subject Headings Russian	D019674	L0894372	no	S1098189	Y	GENY T-KLETOCHNYKH RETSEPTOROV BETA
Russian	Medical Subject Headings Russian	D019674	L1544793	no	S1840702	Y	T-KLETOCHNYKH BETA-RETSEPTOROV GENY
Russian	Medical Subject Headings Russian	D019674	L1544797	no	S1840706	Y	T-KLETOCHNYKH RETSEPTOROV BETA GENY
Russian	Medical Subject Headings Russian	D019674	L3336569	no	S3864131	Y	T-КЛЕТОЧНЫХ БЕТА-РЕЦЕПТОРОВ ГЕНЫ
Russian	Medical Subject Headings Russian	D019674	L3336573	no	S3864135	Y	T-КЛЕТОЧНЫХ РЕЦЕПТОРОВ БЕТА ГЕНЫ
	Medical Subject Headings				A0950501	AT38149641	DNA sequences encoding the beta chain of the T-cell receptor. The genomic organization of the TcR beta genes is essentially the same in all species and is similar to the organization of Ig genes.
	NCI Thesaurus				A7625365	AT197954577	This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. (from LocusLink)