:root {
  --p: #0077B6; --pd: #005a8c; --navy: #0b2540; --navy2: #12365c;
  --bg: #f5f8fb; --surface: #fff; --text: #17202e; --muted: #5a6577; --line: #e2e8f0;
  --l4: #b4232f; --l4bg: #fdecee;
  --l3: #d9480f; --l3bg: #fff1e8;
  --l2: #b7791f; --l2bg: #fff8e1;
  --l1: #4a6fa5; --l1bg: #eef3fa;
  --ok: #2f855a; --okbg: #e9f7ef;
  --sh: 0 1px 2px rgba(16,24,40,.05), 0 6px 20px rgba(16,24,40,.07);
}
* { box-sizing: border-box; }
body { margin: 0; font-family: Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; color: var(--text); background: var(--bg); line-height: 1.55; font-size: 16px; }
a { color: var(--p); text-decoration: none; }
a:hover { text-decoration: underline; }
h1, h2, h3 { margin: 0; line-height: 1.2; letter-spacing: -.015em; }
p { margin: 0; }
.wrap { max-width: 1100px; margin: 0 auto; padding: 0 20px; }
.sr-only { position: absolute; width: 1px; height: 1px; overflow: hidden; clip: rect(0 0 0 0); }

.btn { display: inline-flex; align-items: center; justify-content: center; gap: 6px; font: 600 15px Inter, system-ui, sans-serif; padding: 11px 18px; border-radius: 12px; border: 1px solid transparent; cursor: pointer; white-space: nowrap; }
.btn.primary { background: var(--p); color: #fff; box-shadow: 0 6px 16px rgba(0,119,182,.3); }
.btn.primary:hover { background: var(--pd); }
.btn.primary:disabled { opacity: .6; cursor: wait; }
.btn.ghost { background: #fff; color: var(--p); border-color: #cfe0ee; }
.btn.ghost:hover { border-color: var(--p); }
.btn.small { padding: 7px 12px; font-size: 14px; border-radius: 10px; }

/* Header */
.top { background: #fff; border-bottom: 1px solid var(--line); }
.top .wrap { display: flex; align-items: center; justify-content: space-between; min-height: 66px; gap: 12px; flex-wrap: wrap; }
.logo { display: flex; align-items: center; gap: 10px; color: var(--navy); text-decoration: none !important; }
.logo-mark { width: 38px; height: 38px; border-radius: 11px; background: linear-gradient(135deg, var(--p), #12a3a3); color: #fff; font-weight: 800; display: grid; place-items: center; font-size: 19px; }
.logo b { display: block; font-size: 19px; font-weight: 800; line-height: 1.1; }
.logo small { display: block; font-size: 12px; color: var(--muted); }
.top nav { display: flex; gap: 4px; }
.top nav a { color: #3c4757; font-weight: 500; font-size: 15px; padding: 8px 10px; border-radius: 8px; }
.top nav a:hover { background: #eef6fc; color: var(--p); text-decoration: none; }

/* Entry */
.hero { background: radial-gradient(900px 400px at 90% -20%, rgba(18,163,163,.4), transparent 60%), linear-gradient(160deg, var(--navy), var(--navy2)); color: #fff; padding: 40px 0 44px; }
.hero h1 { font-size: clamp(26px, 3.6vw, 38px); font-weight: 800; }
.hero > .wrap > p { color: #c9d6e6; margin: 10px 0 22px; max-width: 760px; }
.entry { background: #fff; border-radius: 20px; padding: 18px; box-shadow: 0 24px 50px rgba(0,0,0,.25); color: var(--text); }
.entry textarea { width: 100%; min-height: 170px; resize: vertical; border: 2px solid #d5dee8; border-radius: 14px; padding: 14px 16px; font: 500 16px/1.6 Inter, system-ui, sans-serif; color: var(--text); }
.entry textarea:focus { outline: none; border-color: var(--p); box-shadow: 0 0 0 5px rgba(0,119,182,.14); }
.entry-bar { display: flex; flex-wrap: wrap; gap: 12px; align-items: center; justify-content: space-between; margin-top: 12px; }
.hint { font-size: 13.5px; color: var(--muted); flex: 1 1 300px; }
.entry-actions { display: flex; gap: 8px; flex-wrap: wrap; }

.status { max-width: 1060px; margin: 18px auto 0; padding: 12px 16px; border-radius: 12px; background: #e6f1fa; color: var(--navy); font-weight: 500; }
.status.error { background: var(--l4bg); color: var(--l4); }
.status .spinner { display: inline-block; width: 14px; height: 14px; border: 2px solid currentColor; border-right-color: transparent; border-radius: 50%; margin-right: 8px; vertical-align: -2px; animation: spin .8s linear infinite; }
@keyframes spin { to { transform: rotate(360deg); } }

/* Results */
main { padding-top: 22px; padding-bottom: 20px; }
.summary { display: grid; grid-template-columns: repeat(auto-fit, minmax(150px, 1fr)); gap: 10px; margin-bottom: 18px; }
.kpi { background: #fff; border: 1px solid var(--line); border-radius: 14px; padding: 12px 14px; box-shadow: var(--sh); border-top: 4px solid var(--line); }
.kpi b { display: block; font-size: 26px; font-weight: 800; line-height: 1.1; }
.kpi span { font-size: 13px; color: var(--muted); }
.kpi.l4 { border-top-color: var(--l4); } .kpi.l4 b { color: var(--l4); }
.kpi.l3 { border-top-color: var(--l3); } .kpi.l3 b { color: var(--l3); }
.kpi.l2 { border-top-color: var(--l2); } .kpi.l2 b { color: var(--l2); }
.kpi.l1 { border-top-color: var(--l1); } .kpi.l1 b { color: var(--l1); }

.block { background: #fff; border: 1px solid var(--line); border-radius: 18px; padding: 20px; box-shadow: var(--sh); margin-bottom: 18px; }
.block-head { display: flex; align-items: center; justify-content: space-between; gap: 10px; margin-bottom: 14px; }
.block h2 { font-size: 20px; font-weight: 800; }

.drug-list { display: grid; grid-template-columns: repeat(auto-fill, minmax(250px, 1fr)); gap: 10px; }
.drug { border: 1px solid var(--line); border-radius: 12px; padding: 11px 13px; font-size: 14px; }
.drug .in { color: var(--muted); font-size: 12.5px; }
.drug .name { font-weight: 700; font-size: 15.5px; margin: 2px 0; }
.drug .meta { color: var(--muted); font-size: 13px; }
.drug.missing { border-color: #f3c2c7; background: var(--l4bg); }
.drug.missing .name { color: var(--l4); }
.drug .tag { display: inline-block; font-size: 11px; font-weight: 700; padding: 1px 7px; border-radius: 6px; background: #eef2f7; color: #475467; margin-left: 4px; vertical-align: 1px; }

/* Matrix */
.matrix-wrap { overflow-x: auto; margin-bottom: 16px; }
.matrix { border-collapse: separate; border-spacing: 3px; font-size: 12.5px; }
.matrix th { font-weight: 600; color: var(--muted); padding: 2px 6px; white-space: nowrap; }
.matrix thead th { writing-mode: vertical-rl; transform: rotate(180deg); text-align: left; height: 150px; max-height: 150px; vertical-align: bottom; }
.matrix tbody th { text-align: right; }
.matrix td { width: 30px; height: 30px; border-radius: 7px; background: #f2f5f9; text-align: center; font-weight: 800; color: #fff; }
.matrix td.self { background: transparent; }
.matrix td.l4 { background: var(--l4); } .matrix td.l3 { background: var(--l3); }
.matrix td.l2 { background: var(--l2); } .matrix td.l1 { background: var(--l1); }
.matrix td a { display: block; color: inherit; text-decoration: none; line-height: 30px; }
.legend { display: flex; flex-wrap: wrap; gap: 6px 14px; font-size: 13px; color: var(--muted); margin-top: 8px; }
.legend i { display: inline-block; width: 12px; height: 12px; border-radius: 3px; margin-right: 5px; vertical-align: -1px; }

/* Interaction cards */
.ix { border: 1px solid var(--line); border-left: 6px solid var(--l1); border-radius: 14px; padding: 14px 16px; margin-bottom: 12px; scroll-margin-top: 20px; }
.ix.l4 { border-left-color: var(--l4); background: linear-gradient(90deg, var(--l4bg), #fff 40%); }
.ix.l3 { border-left-color: var(--l3); background: linear-gradient(90deg, var(--l3bg), #fff 40%); }
.ix.l2 { border-left-color: var(--l2); }
.ix-head { display: flex; flex-wrap: wrap; align-items: center; gap: 8px 12px; margin-bottom: 8px; }
.ix-head h3 { font-size: 17px; font-weight: 800; }
.badge { display: inline-block; font-size: 12px; font-weight: 700; padding: 3px 10px; border-radius: 999px; color: #fff; background: var(--l1); }
.badge.l4 { background: var(--l4); } .badge.l3 { background: var(--l3); } .badge.l2 { background: var(--l2); }
.badge.soft { background: #eef2f7; color: #475467; font-weight: 600; }
.finding { padding: 9px 0; border-top: 1px dashed var(--line); font-size: 14.5px; }
.finding:first-of-type { border-top: none; }
.finding .src { font-size: 12.5px; color: var(--muted); font-weight: 600; margin-bottom: 2px; }
.finding .src em { font-style: normal; color: #344050; }
.finding .lvl { display: inline-block; width: 9px; height: 9px; border-radius: 50%; margin-right: 6px; background: var(--l1); }
.finding .lvl.l4 { background: var(--l4); } .finding .lvl.l3 { background: var(--l3); } .finding .lvl.l2 { background: var(--l2); }
mark { background: #fff1a8; color: inherit; padding: 0 2px; border-radius: 3px; }
.more { background: none; border: none; padding: 6px 0 0; color: var(--p); font: 600 14px Inter, sans-serif; cursor: pointer; }
.empty { padding: 14px 16px; border-radius: 12px; background: var(--okbg); color: var(--ok); font-weight: 500; }
.muted-list { font-size: 13.5px; color: var(--muted); margin-top: 12px; }

.food-drug { margin-bottom: 18px; }
.food-drug h3 { font-size: 16px; font-weight: 800; margin-bottom: 8px; }
.food-drug h3 small { font-weight: 500; color: var(--muted); font-size: 13px; }
.food-grid { display: grid; grid-template-columns: repeat(auto-fill, minmax(320px, 1fr)); gap: 10px; }
.food-grid .ix { margin: 0; }
.food-grid .ix-head h3 { font-size: 15px; }

.foot { color: var(--muted); font-size: 13.5px; padding-top: 6px; padding-bottom: 40px; display: grid; gap: 10px; }
.foot b { color: var(--text); }

@media (max-width: 640px) {
  .wrap { padding: 0 16px; }
  .hero { padding: 28px 0 32px; }
  .entry { padding: 12px; border-radius: 16px; }
  .entry-actions { width: 100%; }
  .entry-actions .btn.primary { flex: 1 1 100%; order: -1; }
  .entry-actions .btn.ghost { flex: 1; }
  .block { padding: 16px 14px; }
  .food-grid { grid-template-columns: 1fr; }
  .top nav { display: none; }
}

@media print {
  .top, .hero, .status, .foot p:first-child, #print, .more { display: none !important; }
  body { background: #fff; font-size: 12px; }
  .block { box-shadow: none; break-inside: avoid-page; }
  .ix { break-inside: avoid; }
  .hidden-finding { display: block !important; }
  main::before { content: "Drug interaction screening (FDA label text) — doctor.am"; display: block; font-weight: 800; font-size: 16px; margin-bottom: 10px; }
}