Classification Nuance. The OpenFDA dataset, which draws from the Structured Product Labeling (SPL) files, often includes multiple classification fields, and the specific string "Phosphate Binder [EPC]" may only be assigned to a single product. The other drugs are likely classified using: More Specific Classes: Many of those drugs (like sevelamer, ferric citrate, etc.) may be classified by their specific mechanism or chemical group, which also acts as a phosphate binder. Example: A drug might be classified as "Iron-Containing Compound [EPC]" or "Aluminum-Containing Compound [EPC]" instead of the more general "Phosphate Binder [EPC]". Different Classification Fields: The NDC data contains several classification fields. You might be checking the Established Pharmacological Class (pharm_class_epc), but the other drugs might be listed under: Mechanism of Action (pharm_class_moa), Physiological Effect (pharm_class_pe)
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Endothelin Receptor Antagonist [EPC]

NDC Number Brand Name Generic Name Manufacturer Dosage Form DEA Sch. Marketing Start Date
0378-4270 Ambrisentan ambrisentan Mylan Pharmaceuticals Inc. TABLET, FILM COATED 2019-04-29
0378-4271 Ambrisentan ambrisentan Mylan Pharmaceuticals Inc. TABLET, FILM COATED 2019-04-29
0591-2405 Ambrisentan Actavis Pharma, Inc. TABLET, FILM COATED 2019-03-28
0591-2406 Ambrisentan Ambrisentan Actavis Pharma, Inc. TABLET, FILM COATED 2019-04-30
42794-051 AMBRISENTAN AMBRISENTAN Sigmapharm Laboratories, LLC TABLET, FILM COATED 2019-04-10
42794-052 AMBRISENTAN AMBRISENTAN Sigmapharm Laboratories, LLC TABLET, FILM COATED 2019-04-10
47335-236 ambrisentan ambrisentan Sun Pharmaceutical Industries, Inc. TABLET, FILM COATED 2019-04-29
47335-237 ambrisentan ambrisentan Sun Pharmaceutical Industries, Inc. TABLET, FILM COATED 2019-04-29
50090-7670 ambrisentan ambrisentan A-S Medication Solutions TABLET, FILM COATED 2022-07-21
50090-7671 ambrisentan ambrisentan A-S Medication Solutions TABLET, FILM COATED 2022-07-21
59651-494 ambrisentan ambrisentan Aurobindo Pharma Limited TABLET, FILM COATED 2022-07-21
59651-495 ambrisentan ambrisentan Aurobindo Pharma Limited TABLET, FILM COATED 2022-07-21
60505-4552 Ambrisentan AMBRISENTAN Apotex Corp. TABLET, FILM COATED 2022-09-19
60505-4553 Ambrisentan AMBRISENTAN Apotex Corp. TABLET, FILM COATED 2022-09-19
61958-0801 Letairis AMBRISENTAN Gilead Sciences, Inc. TABLET, FILM COATED 2007-06-15
61958-0802 Letairis AMBRISENTAN Gilead Sciences, Inc. TABLET, FILM COATED 2007-06-15
65162-873 Bosentan Bosentan Amneal Pharmaceuticals LLC TABLET, FILM COATED 2019-04-26
65162-874 Bosentan Bosentan Amneal Pharmaceuticals LLC TABLET, FILM COATED 2019-04-26
66215-501 OPSUMIT macitentan Actelion Pharmaceuticals US, Inc. TABLET, FILM COATED 2013-11-04
66215-812 OPSYNVI macitentan and tadalafil Actelion Pharmaceuticals US, Inc. TABLET, FILM COATED 2024-03-22
66215-814 OPSYNVI macitentan and tadalafil Actelion Pharmaceuticals US, Inc. TABLET, FILM COATED 2024-03-22
68974-200 FILSPARI sparsentan Travere Therapeutics, Inc. TABLET, FILM COATED 2023-02-17
68974-400 FILSPARI sparsentan Travere Therapeutics, Inc. TABLET, FILM COATED 2023-02-17
69097-386 Ambrisentan Ambrisentan Cipla USA Inc. TABLET, FILM COATED 2019-04-26
69097-387 Ambrisentan Ambrisentan Cipla USA Inc. TABLET, FILM COATED 2019-04-26
70710-1179 Ambrisentan Ambrisentan Zydus Pharmaceuticals USA Inc. TABLET, FILM COATED 2019-04-12
70710-1180 Ambrisentan Ambrisentan Zydus Pharmaceuticals USA Inc. TABLET, FILM COATED 2019-04-12
70771-1363 Ambrisentan Ambrisentan Zydus Lifesciences Limited TABLET, FILM COATED 2019-04-12
70771-1364 Ambrisentan Ambrisentan Zydus Lifesciences Limited TABLET, FILM COATED 2019-04-12
80491-8012 TRYVIO Aprocitentan Idorsia Pharmaceuticals Ltd TABLET, FILM COATED 2024-03-20
82009-141 Ambrisentan Ambrisentan Quallent Pharmaceuticals Health LLC TABLET, FILM COATED 2024-05-01
82009-142 Ambrisentan Ambrisentan Quallent Pharmaceuticals Health LLC TABLET, FILM COATED 2024-05-01



 [EPC] Established Pharmacological Classification 

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